The emerging role of IL-38 in diseases: A comprehensive review

Abstract

Introduction: Interleukin-38 (IL-38) is a new type of anti-inflammatory cytokine, which is mainly expressed in the immunity-related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases. Aim: This review aims to detail the biological function, receptors and signaling of IL-38, which highlights its therapeutic potential in related diseases. Conclusion: This article provides a comprehensive review of the association between interleukin-38 and related diseases, using interleukin-38 as a keyword and searching the relevant literature through Pubmed and Web of science up to July 2023.