IL-10 control of dendritic cells in the skin

Abstract

Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Mice bearing a dendritic cell (DC)-specific defect in the IL-10 receptor mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key function of DCs in the maintenance of local immune homeostasis. © 2013 Landes Bioscience.