Neonatal mortality rate and risk factors in northeast China: Analysis of 5,277 neonates in 2005

Abstract

Background: Healthcare has dramatically improved for both mothers and neonates over the last three decades in China. However, the reported rates of morbidity and mortality vary among different regions of China, and the exact rates in Northeast China are unknown. This study aimed to determine neonatal morbidity and mortality rates and the associated risk factors in Northeast China. Materials and Meth- ods: Neonates born in 2005 at seven hospitals in five major cities of Heilongjiang province in Northeast China were recruited. Standard- ized questionnaires on both the mother and neonate were conducted by trained investigators. The questions included demographic data on the mother, the mother's weight, gestational age (GA), complications during pregnancy, method of delivery, neonate's gender, weight, general health situation, and complications after delivery. Results: A total of 5,277 neonates were included, with a male to female ratio of 1.07. The incidence of preterm delivery was 8.7%, which was associated with an increased age of the mother, a history of preeclampsia-eclampsia, premature rupture of membranes, and intrauterine distress. Morbidity occurred in 7.0% of neonates, including hypoxic ischemic encephalopathy (2.4%), asphyxia (1.6%), pneumonia (1.6%), hyperbilirubinemia (0.5%), intracranial hemorrhage (0.5%), meconium as- piration syndrome (02%), and ingestion syndrome (0.2%). The overall mortality was 9.5%o. Preterm delivery, maternal history of preeclamp- sia-eclampsia, hypoxic ischemic encephalopathy, intracranial hemorrhage, pneumonia, asphyxia, and meconium aspiration syndrome were independent risk factors for mortality with odds ratios (95% confidence interval) of 17.42 (7.31-38.9), 12.52 (Table 3) (3.91-16.82), 10.13 (2.52-19.86), 9.77 (2.35-19.93), 4.15 (1.78-9.52), 2.18 (1.21-5.47), and 2.76 (2.11-6.32), respectively (all P< 0.01). Conclusions: In 2005, the overall morbidity and mortality was 7.0% and 9.5%o, the overall morbidity ana mortality was /.U% and y.0%0, respectively in northeast China, ana preterm delivery was the highest risk factor for neonatal mortality The prevention on preterm delivery should be a top priority for the improvement of neonatal healthcare.