Transient global amnesia

Abstract

Transient global amnesia (TGA) is a memory dysfunction characterized by a sudden onset of dense anterograde amnesia (AA) that gradually resolves across several hours. TGA is typically accompanied by repeated questions (concerning present circumstances) with retrograde amnesia for events preceding the attack, and it usually strikes individuals in their late 50s and early 60s. The etiology of TGA remains unclear, although it probably reflects a temporary disruption of the blood supply to the temporal lobe. The physical and psychological events preceding the attack are diverse, but they often include acute emotional and physical stressors. TGA appears to be benign, with low risk for recurrence or residual complications. While systematic memory research on TGA patients is rare, these individuals present a unique opportunity to study amnestic behaviors in otherwise normal individuals. A guide to conducting future research is provided.