Genital fixed drug eruptions

Abstract

Twenty nine patients with genital fixed drug eruptions were studied during one year. In 15 the genitalia were exclusively affected, whereas the other 14 had cutaneous lesions in addition. It was striking that those whose lesions were exclusively genital reported for consultation much earlier. Drug history was the mainstay of diagnosis. Provocation tests with graded doses of the suspected drug(s) were undertaken in all cases. Tetracycline was the commonest causative drug, followed by oxyphenbutazone and acetylsalicyclic acid.