Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L

Abstract

We have recently isolated two genes encoding proteins which have either homology or affinity to RBP-J, a transcription factor involved in Notch signaling. Kyo-T interacts with RBP-J and possibly regulates the function of RBP-J. RBP-L has a highly homologous region with RBPJ but the function of RBP-L is unknown. Fluorescence in situ hybridization analysis of human metaphase chromosomes localized Kyo-Tand RBP-L to Xq26 and 20q12-13.1, respectively.