Modeling hematopoietic disorders in zebrafish

28Citations
Citations of this article
71Readers
Mendeley users who have this article in their library.

Abstract

Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.

References Powered by Scopus

The zebrafish reference genome sequence and its relationship to the human genome

3753Citations
N/AReaders
Get full text

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

3158Citations
N/AReaders
Get full text

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

3115Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Stress erythropoiesis: definitions and models for its study

69Citations
N/AReaders
Get full text

Effectiveness of zebrafish models in understanding human diseases—A review of models

64Citations
N/AReaders
Get full text

NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation

59Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Konantz, M., Schürch, C., Hanns, P., Müller, J. S., Sauteur, L., & Lengerke, C. (2019). Modeling hematopoietic disorders in zebrafish. DMM Disease Models and Mechanisms, 12(9). https://doi.org/10.1242/dmm.040360

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 28

65%

Professor / Associate Prof. 8

19%

Researcher 6

14%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 24

56%

Medicine and Dentistry 8

19%

Agricultural and Biological Sciences 6

14%

Immunology and Microbiology 5

12%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 21

Save time finding and organizing research with Mendeley

Sign up for free