Raman spectroscopy analysis for monitoring of chemical composition of aspirin after exposure to plasma flame

Abstract

A Raman spectroscopy method was optimised to examine the chemical changes of aspirin tablets after interaction with helium temperatures. Several aspirin tablets were exposed to plasma-assisted desorption ionisation flame for different times (10, 30, 50, 60, 180 and 300 s) and then analysed by Raman spectroscopy using optimal conditions. The changes in chemistry between exposed and fresh (without exposure to plasma) tablets were compared. The vibrational peaks of the aspirin molecule in the Raman spectrum were identified by checking the peak position. The results showed clear spectra with increases in intensity of vibrational peaks until 30 s, whereas no spectra were measured for the exposed tablets to plasma flame after 50 s. It can, therefore, be assumed that the chemistry structure of aspirin compound might be damaged by exposure to high temperature.