A Simple Electrochemical Method for Determination of Rosuvastatin Calcium in Cholesterol-Lowering Medical Products

Abstract

Rosuvastatin is belonged to a class of medicine used to reduce “bad” cholesterol levels in human beings’ bodies, and it is being manufactured more and more to serve medical purposes. Herein, an electrochemical method was reported for the determination of rosuvastatin using the activated glassy carbon electrode with differential pulse voltammogram. In this study, the measured parameters, including the accumulation time, pH, and supporting electrolyte, for the quantification of rosuvastatin were optimized. The results demonstrated the linear range from 0.15 mg L-1 to 2.5 mg L-1. The limit of detection (LOD) and limit of quantification (LOQ) were estimated as 0.035 mg L-1 and 0.12 mg L-1, respectively. The concentration difference of rosuvastatin in commercial drug samples between the determination from the proposed electrochemical method and the published values of the manufacturer was 0.10% ÷ 1.10%, the recovery varied from 98.6% to 101.1%. The proposed electrochemical method was then compared to HPLC-UV as an arbitration method, and the obtained difference was of 0.10% ÷ 1.10% between the two methods. The proposed electrochemical method in this current study performed high potential of application in controlling the quantity of rosuvastatin during the production process and even in commercial drug tablets that are available in many drugstores due to the direct determination and various advantages, such as simple, quick, labor-saving, and relatively inexpensive compared to the chromatographic approaches.