Effect of ubiquinol on exercise and the oxidative stress regulation system in SMAP1 mice

Abstract

[Purpose] This study examined how exercise capacity and the oxidative stress regulation system are affected by different amounts of consumed ubiquinol (reduced coenzyme Q10, H2CoQ10: QH) through experiments on 23 SAMP1 mice. [Methods] The mice were randomly divided into two groups: one consuming a high amount of QH (300 mg/Kg) and the other consuming a low amount of QH (30 mg/Kg). Both groups were made to run up to their limit on a treadmill (TM) before/after consuming QH, and then each running time was measured. For the oxidative stress regulation system, the d-ROM test value (degree of oxidative stress) and BAP test value (anti-oxidant potential) were measured both in a resting state before QH consumption and after running up to the limit, and then the BAP/d-ROM ratio was calculated. The values of plasma QH and plasma ubiquinone (plasma oxidized CoQ10) were also measured, and the reduced ratio was calculated. [Results] Both groups showed a significant extension of running time. Also, a more significant extension was seen in the group consuming a high amount of QH than in the group consuming a low amount. With regard to the oxidative stress regulation system, the group consuming a high amount also showed a significant increase in d-ROM test value, plasma QH value and reduced ratio. [Conclusion] The difference in the amount of consumed ubiquinol led to an extension of running time and an increase in reduced ratio and other values.