Neuroprotective effects of hypoactive Akkermansia muciniphila in MPTP-induced mouse models of Parkinson’s disease

Abstract

Recent research suggests a connection between Parkinson’s disease (PD) and the microbiota-gut-brain axis, with evidence indicating that probiotics may alleviate PD symptoms. Although Akkermansia muciniphila has demonstrated potential benefits for certain neurological disorders, its efficacy in the treatment of PD is still a subject of ongoing debate. Here, we demonstrated that hypoactive Akkermansia muciniphila ameliorated dopaminergic neuronal death, correlating to the reduction of glial hyperactivation and neuroinflammation. Hypoactive Akkermansia muciniphila also induced microbiota fluctuation, which may perform a sophisticated effect on PD progression. Our study may provide an innovative strategy for using hypoactive Akkermansia muciniphila as a therapy or adjuvant therapy for PD.