Pradimicins m, n, O and p, new dihydrobenzo(a)naphthacenequinones produced by blocked mutants of actinomadura hibisca p157-2

Abstract

Four blocked mutants which accumulated new dihydrobenzo[a]naphthacenequinone metabolites, designated pradimicins M, N, O and P, have been isolated from cultures of mutants of Actinomadura hibisca PI57-2 resulting from treatment with N-methyl-N1-nitro-N-nitrosoguanidine. The structures of the four compounds were determined by spectral analysis. Pradimicins N, O and P contain D-alanine, while pradimicin M does not. The conformations at C-5 and C-6 of these compounds are different from those of the original pradimicins. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.