Development and In-vitro characterization of floating drug delivery system of ketoconazole

Abstract

The oral route is increasingly being used for the delivery of therapeutic agents because the low cost of the therapy and ease of administration lead to high level of patient compliances.  Floating drug delivery system (FDDS) float in the gastric fluid and prolong GRT to obtain sufficient drug bioavailability, because of their lower bulk density compared to that of the aqueous medium. The aim of the present study is to prepare floating tablets as a delivery system for controlled release of Ketoconazole. Ketoconazole is a drug of choice in antifungal category and gives significant result. Floating tablets containing Ketoconazole were prepared by direct compression technique using varying concentrations of different grades of polymers of Hydrxy Propyl Cellulose & Xanthan gum. To evaluate the prepared floating tablets for various parameters like hardness, friability, uniformity of drug content, in-vitro floating studies, in-vitro dissolution studies. Keywords: Ketoconazole, Floating drug delivery system, Hydrxy Propyl Cellulose, Xanthan gum