Synthesis and reactions of new thienopyridines, pyridothienopyrimidines and pyridothienotriazines

Abstract

4-Aryl-3-cyano-6-(2′-thienyl)-pyridine-2(1H)-thiones (1a-c) were reacted with phenacyl bromide, chloro-N-arylacetamides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respectively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.