Some Metabolic Effects of Sodium Nitroprusside in Man

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Abstract

The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B12 tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions the ratio of methylcobalamin to adenosyl + hydroxocobalamin fell and cyanocobalamin concentrations were high. © 1974, British Medical Journal Publishing Group. All rights reserved.

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Vesey, C. J., Cole, P. V., Linnell, J. C., & Wilson, J. (1974). Some Metabolic Effects of Sodium Nitroprusside in Man. British Medical Journal, 2(5911), 140–142. https://doi.org/10.1136/bmj.2.5911.140

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