Research Progress on Functional Modifications and Applications of Bioceramic Scaffolds

Abstract

Porous bioceramic scaffolds, which possess attractive biocompatibility, ability to guide tissue regeneration and porous surface morphologies and channels beneficial to ingrowth of new born tissues, have seized increasing attentions and been widely applied in the field of hard tissue restoration. Whereas, the weak osteoinductive activity, monotonous biological function and poor mechanical property have restrained the therapeutic efficacy and wider application of bioceramic scaffolds. In view of this, we intended to introduce the existing modification methods of bioceramic scaffolds, including the surface modification with functional coating, construction of surface micro-/nano- structures, functional element doping and enhancement of mechanical property, along with the state of the research progresses in the improvement of biocompatibility, bone defect restoration, drug delivery, tumor therapy, and antiba¬cterial capacity of multifunctional bioceramic scaffolds. In addition, potential research directions and applications of functionally modified bioceramic scaffolds are prospected to provide references for the related exploration afterwards.