Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels

95Citations
Citations of this article
58Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

OBJECTIVE-It has been suggested that retinol-binding protein 4 (RBP4) links adiposity, insulin resistance, and type 2 diabetes. However, circulating RBP4 levels are also affected by kidney function. Therefore, the aim of this study was to test whether RBP4 serum levels are primarily associated with kidney function or type 2 diabetes. RESEARCH DESIGN AND METHODS-RBP4 serum concentration was determined by enzyme-linked immunosorbent assay in 126 nondiabetic and 104 type 2 diabetic subjects. The study population was divided according to estimated glomerular filtration rate (eGFR) into the following groups: eGFR >90 ml/min per 1.73 m2 (n = 53), 60-90 ml/min per 1.73 m2 (n=90), 30-60 ml/min per 1.73 m2 (n=38), and <30 ml/min per 1.73 m2 (n=49). Each group was subdivided into nondiabetic and type 2 diabetic subjects. RESULTS-RBP4 serum concentration was elevated (2.65 vs. 2.01 μmol/l; P < 0.001) and eGFR was reduced (56 vs. 74 ml/min per 1.73 m2; P < 0.001) in type 2 diabetic vs. nondiabetic subjects, respectively. By stratifying for eGFR, no more differences in RBP4 serum concentration were detectable between type 2 diabetic and nondiabetic subjects. A linear regression analysis revealed an influence of eGFR (r=-0.477; P < 0.001) but not A1C (r=0.093; P=0.185) on RBP4 serum concentration. CONCLUSIONS-Existing human data showing elevated RBP4 levels in type 2 diabetic patients may be the result of moderate renal insufficiency rather than support for the suggestion that RBP4 links obesity to type 2 diabetes. © 2008 by the American Diabetes Association.

Cite

CITATION STYLE

APA

Henze, A., Frey, S. K., Raila, J., Tepel, M., Scholze, A., Pfeiffer, A. F. H., … Schweigert, F. J. (2008). Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels. Diabetes, 57(12), 3323–3326. https://doi.org/10.2337/db08-0866

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free