Antiasthmatic activity of 2-piperidone by selective animal models

Abstract

2-piperidone is a six membered heterocyclic compound existing naturally in piperaceae and portulaceae families. The synthetic derivatives of piperidone are promising bioactive molecules. They are antioxidant and anti-inflammatory agents. Antihistaminic and anticholinergic studies are used as a part of antiasthmatic study. In the current study antihistaminic and anticholinergic studies were carried out using guinea pig bronchi and ilei in naturally isolated compound 2-piperidone from the plant Talinum portulacifolium. The results indicate that the compound (2 mg/kg 10.81 ± 1.29*** at p<0.001) showed profound antihistaminic activity significantly in histamine induced bronchospasm model than standard drug chlorpheniramine (2 mg/kg 8.77±0.43** at ** p<0.01). The compound can be further studied for antiasthmatic activity by various other ways to establish its mechanism of action as well as drug development studies to render it a novel antiasthmatic drug.