Biomimetic Synthesis of the Bicyclic Guanidine Moieties of Crambines A and B

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Abstract

The acyl portions of crambine A (six steps, 29% overall yield) and crambine B (six steps, 26% overall yield) have been efficiently and stereospecifically synthesized from methyl acetoacetate. © 1992, American Chemical Society. All rights reserved.

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Snider, B. B., & Shi, Z. (1992). Biomimetic Synthesis of the Bicyclic Guanidine Moieties of Crambines A and B. Journal of Organic Chemistry, 57(9), 2526–2528. https://doi.org/10.1021/jo00035a005

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