Isolation of pyrethrosin derivatives from the flower of Chrysanthemum coronarium L.

Abstract

From the chloroform ext. of Chrysanthemum coronarium L. flowers, three sesquiterpene lactones were isolated by the repeated silica gel column chromatog. and recrystn. and were identified as pyrethrosin (I), 1,10-epipyrethrosin (II), and tulirinol (III). Their structures were detd. using various spectroscopic data. Compds. I-III, reported for the first time in this plant, showed strong cytotoxic activities against A549, PC-3 and HCT-15 human cancer cell lines with GI50 values ranging 1.5-3.5 μg · mL-1. [on SciFinder(R)]