Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

Abstract

Pham et al. show that granulomas in Salmonella-infected tissues are composed of macrophages that exhibit heterogenous polarization states, or phenotypes, and are functionally distinct. They elucidate a pathogen-driven virulence mechanism that controls granuloma macrophage polarization and long-term pathogen persistence during Salmonella infection.