Bioactive isoflavones from Dalbergia vacciniifolia (Fabaceae)

Abstract

Three new 5-dehydroxy isoflavone compounds, 6,2′-dimethoxy-7, 4′-dihydroxyisoflavone (1), 6,2′,4′-trimethoxy-7- hydroxyisoflavone (2), and 6,2′,4′,5′-tetramethoxy-7-O- [β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside] isoflavone (3), along with a known isoflavone, 6,2′,4′,5′-tetramethoxy-7- hydroxyisoflavone (4), were isolated from the ethanolic extract of Dalbergia vacciniifolia Vatke. Their structures were established by spectroscopic techniques including one- and two-dimension NMR. Compound 1 showed mild cytotoxic activity against brine shrimp larvae with a LC50 value of 266 μg/mL.