Elevated serum ykl-40, il-6, crp, cea, and ca19-9 combined as a prognostic biomarker panel after resection of colorectal liver metastases

16Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

Background The inflammatory biomarkers, YKL-40 and interleukin-6 (IL-6), are elevated in patients with metastatic colorectal cancer. We examined their associations with relapse-free survival and overall survival in combination with serum C-reactive protein (CRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 19 9 (CA19-9) in patients with colorectal liver metastases. Methods Altogether 441 consecutive patients undergoing liver resection at Helsinki University Hospital between 1998 and 2013 were included in the study. Pre- and postoperative YKL-40 and IL-6 were determined from serum samples with commercially available enzyme-linked immunosorbent assay (ELISA) kits, and CRP, CEA, and CA19-9 by routine methods. Associations between these biomarkers and relapse-free and overall survival were examined using Cox regression analysis. Results Patients with 2 5 elevated biomarkers were at an increased risk of relapse compared to those with 0 1 elevated biomarkers, preoperatively (HR 1.37, 95% CI 1.1 1.72) or postoperatively (HR 1.54, 95% CI 1.23 1.92). Patients with 2 5 elevated biomarkers were also at an increased risk of death compared to those with 0 1 elevated biomarkers, preoperatively (HR 1.76, 95% CI 1.39 2.24) or postoperatively (HR 1.83, 95% CI 1.44 2.33). Conclusion The results suggest that a protein panel of the inflammatory biomarkers YKL-40, IL-6, and CRP, and the cancer biomarkers CEA and CA19-9 might identify patients that benefit from more aggressive treatment and surveillance, although the additional value of IL-6 and CRP in this aspect is limited.

Cite

CITATION STYLE

APA

Peltonen, R., Gramkow, M. H., Dehlendorff, C., Osterlund, P. J., Johansen, J. S., & Isoniemi, H. (2020). Elevated serum ykl-40, il-6, crp, cea, and ca19-9 combined as a prognostic biomarker panel after resection of colorectal liver metastases. PLoS ONE, 15(8 August 2020). https://doi.org/10.1371/journal.pone.0236569

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free