An enantioselective synthesis of the C24-C40 fragment of (−)-pulvomycin

Abstract

The C24-C40 fragment of (−)-pulvomycin was prepared in enantiomerically pure form using a concise synthesis method (15 linear steps from d-fucose, 6.8% overall yield) featuring a diastereoselective addition to an aldehyde, a β-selective glycosylation and a Stille cross-coupling as the key steps. © 2014 Partner Organisations.