18F-alfatide II PET/CT for identification of breast cancer: A preliminary clinical study

Abstract

18F-alfatide II has been proven to have excellent clinical translational potential. In this study, we investigated18F-alfatide II for identifying breast cancer and compared the performances between18F-alfa-tide II and18F-FDG. Methods: Forty-four female patients with suspected primary breast cancer were recruited. PET/CT images using18F-alfatide II and18F-FDG were acquired within 7 d. Tracer uptake in breast lesions was evaluated by visual analysis, and semiquanti-tative analysis with SUVmax and SUVmean. Results: Forty-two breast cancer lesions and 11 benign breast lesions were confirmed by histopathology in 44 patients. Both18F-alfatide II and18F-FDG had higher uptake in breast cancer lesions than in benign breast lesions (P, 0.05 for18F-alfatide II, P, 0.05 for18F-FDG). The area under the curve of18F-alfatide II was slightly less than that of18F-FDG. Both18F-alfatide II and18F-FDG had high sensitivity (88.1% vs. 90.5%), high positive predictive value (88.1% vs. 88.4%), moderate specificity (54.5% vs. 54.5%), and moderate negative predictive value (54.5% vs. 60.0%) for differentiating breast cancer from benign breast lesions. By combining18F-alfatide II and18F-FDG, the sensitivity and negative predictive value significantly increased to 97.6% and 85.7%, respectively, with positive predictive value slightly increased to 89.1% and no change to the specificity (54.5%). The uptake of18F-alfatide II (SUVmax: 3.77 ± 1.78) was significantly lower than that of18F-FDG (SUVmax: 7.37 ± 4.48) in breast cancer lesions (P, 0.05).18F-alfatide II uptake in triple-negative subtype was significantly lower than that in luminal A and luminal B subtypes. By contrast, human epidermal growth factor receptor-2 (HER-2)–overexpressing subtype had higher18F-FDG uptake than the other 3 subtypes. There were 8 breast cancer lesions with higher18F-alfatide II uptake than18F-FDG uptake, which all had a common characteristic that HER-2 expression was negative and estrogen receptor expression was strongly positive. Conclusion:18F-alfatide II is suitable for clinical use in breast cancer patients.18F-alfatide II is of good performance, but not superior to18F-FDG in identifying breast cancer.18F-alfatide II may have superiority to18F-FDG in detecting breast cancer with strongly positive estrogen receptor expression and negative HER-2 expression.