Utility of Kinetic GFR for Predicting Severe Persistent AKI in Critically Ill Children and Young Adults

Abstract

AKI is typically defined by changes in serum creatinine (SCr) and/or urine output. There are several limitations of SCr for the diagnosis of AKI (1,2). Kinetic eGFR (KeGFR)-which relies on a combination of various factors, including initial SCr, rate of creatinine production, volume of distribution (VD), and the change over time allows one to estimate kidney function when the creatinine is changing acutely (3). KeGFR has been validated in various cohorts of adult patients, but there are limited data in pediatric populations (4 8). The purpose of this study was to assess the performance of KeGFR for predicting severe, persistent AKI on day 3 of intensive care unit (ICU) admission in children who are critically ill. We hypothesized that, like in adults, KeGFR would predict AKI.