Synthesis of chiral 3-substituted y-lactones and 9-furanosyl-adenine from (r)-2-(2,2-diethoxyethyl)-l,3-propanediol monoacetate prepared by lipase-catalyzed reaction

Abstract

A chiral building block, (/?)-2-(2,2-diethoxyethyl)-1,3-propanediol monoacetate was synthesized in high optical and chemical yields by lipase-catalyzed transesterification. From this compound, we synthesized chiral 3-substituted y-lactones and a new nucleoside with antiviral activity. © 1991, The Pharmaceutical Society of Japan. All rights reserved.