Human liver CEST imaging at 7 T: Impact of B1+ shimming

Abstract

Purpose: To explore the feasibility of CEST imaging in the human liver at 7 T with (Formula presented.) shimming. Methods: CEST MRI was performed on a 7 T whole-body scanner with a parallel transmission (pTx) system in five healthy volunteers. Static pTx ((Formula presented.) shimming) was applied to locally maximize the (Formula presented.) magnitude per input power within a given region of interest (ROI) of approximately 30 mm diameter (ROIshim). Relaxation-compensated inverse magnetization transfer ratio (MTRRex) values were quantified for amide protons, guanidino protons, and relayed nuclear Overhauser effect signals based on five-pool Lorentzian fit analysis. MTRRex values were corrected for B1 inhomogeneities using an absolute, accurate MR fingerprinting–based (Formula presented.) mapping technique. Results: Within the ROIshim, reliable MTRRex values could be calculated for an average of 85% of voxels. The mean MTRRex values and corresponding coefficient of variations across the group are: 0.113 ± 0.009, 8.8% for amide; 0.167 ± 0.010, 6.3% for nuclear Overhauser effect; and 0.079 ± 0.010, 12.9% for guanidino. MTRRex values exhibit low variation between subjects, as reflected by low coefficient of variations. Conclusion: In this study, we have demonstrated for the first time the feasibility of acquiring and quantifying relaxation-compensated CEST contrasts in the human liver at ultrahigh field. The application of static pTx effectively eliminates (Formula presented.) dropouts and allows for accurate CEST contrast quantification within the selected ROI. In addition, the proposed (Formula presented.) mapping technique shows efficacy for enhanced MTRRex B1 corrections in the abdomen.