The genes to Covid-19 suceptibility

Abstract

COVID-19 is affecting people in very different ways. Among this variability in the susceptibility to COVID-19 some infected people will remain non-symptomatically affected or if they have symptoms, these will be very slight. In other viral infections, the existence of genetic polymorphisms that modify the susceptibility to viral infection and its symptoms has been demonstrated. In the case of COVID-19, genetic polymorphisms have also been identified in different proteins related to the interaction and internament of COVID-19 in the host cell. These genetic polymorphisms identified as single nucleotide polymorphism in genes encoding proteins such as ACE1, ACE2, CD140 or TMPRS have already been associated with greater ease of the virus to infect the cell, but also for infection resistance. It is evident that, the genetic variability of the proteins related to the COVIDS-19-host cell interaction is important, however, it could be also important the existence of genetic polymorphisms located in genes related to the pathological consequences promoted by COVID-19 infection, such as genes related to the thrombo-coagulation system or the inflammatory response. In addition, the influence of other factors including life-style, physical exercise but also co-morbidities may modely genetic-mediated COVID-19 infection.