VASPIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

It was examined 61 patients with type 2 diabetes (m/f: 34/27, disease duration 6.29 ± 0.67 years), overweight or obese, with suboptimal or poor glycemic control, coronary heart disease and/or hypertension were observed. There were no significant changes in the circulating vaspin concentration with respect to control individuals as well as in groups with different gender or the presence/absence of symptomatic coronary heart disease. The patients had no functional relation between the vaspin and parameters of carbohydrate/lipid dismetabolism. The detected relation of vaspin normal levels to proinflammatory resistin (positive) and anti-atherogenic total and highmolecular adiponectin (negative), as well as direct association with the pro-atherogenic adipocytokines leptin and osteoprotegerin only in the preclinical stage of cardiovascular disease development may indicate a compensatory nature of this adipokine influence on vascular complications in type 2 diabetes.