Pharmacological Advances of Coumarin and Its Derivatives

Abstract

Coumarin is a kind of lactone compound with skeleton of benzo-alpha-pyranones, which have favorable druggability due to its advantages of outstanding pharmacological activities, little drug-resistance, lowtoxicity, simple skeleton, easy synthesis and structural modification, and extensive sources. The review summarizes the classification, synthesis methods, pharmacological effects of coumarin and its derivatives. It focuses on their latest progresses in anti-bacteria, anti-virus, anti-inflammation and anti-rheumatism, anti-autoimmune diseases, anti-oxidation, anti-coagulation, anti-cancer and antiangiogenic effects in detail. Especially, coumarins exhibited outstanding effects on clinical difficult miscellaneous diseases with rare drugs, difficult cure and bad prognosis, such as coronavirus disease-19, rheumatoid arthritis, autoimmune neuroinflammation, systemic lupus erythematosus, idiopathic pulmonary fibrosis, etc. The review would provide new skeletons and promising lead compounds with little drug-resistance, high-efficiency and lowtoxicity for new drug development for related diseases based on coumarins. indian porn kamasutra, indian couple sex, sex video hindi xxx, xxx hindi video, Indian hidden camera shower, desi indian xxx hd