The effect of antioxidant supplementation in the treatment of epilepsy

Abstract

Aim: To assess serum level of malondialdehyde (MDA) and total antioxidant status (TAS) as a representative of oxidative stress in patients with generalized epilepsy and to evaluate the therapeutic effect of the antioxidant (vitamin E and vitamin C) on the levels of MDA,TAS and frequency of seizures attacks after two months therapy. for a period of two months as a supplementation therapy. Subjects and Methods: The study was conducted in Iben-seena Hospital in Mosul city-Iraq. Fifty three patients with generalized epilepsy were included in this study (32 male and 21 female). The study included 40 apparently healthy subjects, age and sex matched as a control group. Initially from both the patients and controls, blood samples were taken. Another blood samples were taken from the patients 2 months after vitamin E and vitamin C treatment, blood samples were analysed for serum MDA and serum TAS. Result: Serum MDA was found to be significantly higher (P<0.001) and serum TSA was significantly lower (P<0.001) in patients with generalized epilepsy prior vitamin E and vitamin C supplementation in comparison to controls. After vitamin E and C supplementation there was a significant reduction (P<0.001) in the serum MDA levels with a significant increase (P<0.001) in the serum TAS. Also we found a reduction in seizure frequency of greater than 70% after vitamin E and C supplementation. Conclusion: a significant reduction of TSA was reported in patients with epilepsy. Administration of vitamin E and C produced a significant reduction of serum MAD levels and a significant elevation of serum TAS, associated with a reduction of greater than 70% of seizure frequency. The study suggests the administration of vitamin E and C as adjunct to antiepileptic drugs. Key word: Epilepsy, oxidant /antioxidant status, vitamin E, vitamin C. ‫اﻟﺨﻼﺻﺔ‬ ‫اﻟﻬﺪف‬ : ‫ﻟﺘﻘﻴﻴﻢ‬ ‫اﻟﻤﺎﻟﻮﻧﺪا‬ ‫ﻣﺴﺘﻮﻳﺎت‬ ‫ﻟ‬ ‫ﺪ‬ ‫ﻳ‬ ‫ﻬﺎﻳﺪ‬ MDA ‫اﻟﻜﻠﻲ‬ ‫اﻷآﺴﺪة‬ ‫وﺿﺎدات‬ TAS ‫ﻟﻸآﺴﺪة‬ ‫آﻤﻤﺜﻞ‬ ‫اﻟﺪم‬ ‫ﻣﺼﻞ‬ ‫ﻓﻲ‬ ‫اﻷآﺴﺪة‬ ‫ﻟﻤﻀﺎدات‬ ‫اﻟﻌﻼﺟﻲ‬ ‫اﻟﺘﺄﺛﻴﺮ‬ ‫ﻟﺘﻘﻴﻴﻢ‬ ‫وآﺬاﻟﻚ‬ ‫اﻟﻤﻌﻤﻢ‬ ‫اﻟﺼﺮع‬ ‫ﻣﻦ‬ ‫ﻳﻌﺎﻧﻮن‬ ‫اﻟﺬﻳﻦ‬ ‫اﻟﻤﺮﺿﻰ‬ ‫ﻋﻨﺪ‬ TAS ‫واﻟﺴﻴﻄ‬ ‫ﺮة‬ ‫ﻧﻮﺑ‬ ‫ﻋﻠﻰ‬ ‫ﺗﻜﻤﻴﻠﻲ‬ ‫آﻌﻼج‬ ‫ﺷﻬﺮﻳﻦ‬ ‫ﺑﻌﺪ‬ ‫اﻟﺼﺮع‬ ‫ﺎت‬. ‫اﻟﻄﺮق‬ ‫واﻷﺷﺨﺎص‬ ‫اﻟﻤﺘﺒﻌﺔ‬ : ‫اﻟﺪراﺳ‬ ‫أﺟﺮﻳﺖ‬ ‫اﻟﻤﻮﺻﻞ‬ ‫ﻣﺪﻳﻨﺔ‬ ‫ﻓﻲ‬ ‫ﺳﻴﻨﺎ‬ ‫أﺑﻦ‬ ‫ﻣﺴﺘﺸﻔﻰ‬ ‫ﻓﻲ‬ ‫ﺔ‬-‫اﻟﻌﺮاق‬. ‫هﺬﻩ‬ ‫ﺷﻤﻠﺖ‬ ‫اﻟﻤﺼﺎﺑﻴﻦ‬ ‫اﻟﻤﺮﺿﻰ‬ ‫ﻣﻦ‬ ‫وﺧﻤﺴﻮن‬ ‫ﺛﻼﺛﺔ‬ ‫اﻟﺪراﺳﺔ‬ ‫اﻟﻤﻌﻤﻢ‬ ‫ﺑﺎﻟﺼﺮع‬) ٣٢ ‫اﻟﺬآﻮر‬ ‫ﻣﻦ‬ ، ٢١ ‫اﻹﻧﺎث‬ ‫ﻣﻦ‬ (‫آﺬاﻟﻚ‬ ‫وﺷﻤﻠﺖ‬) ٤٠ (‫وأﺟﻨﺎ‬ ‫أﻋﻤﺎر‬ ‫ﻣﻦ‬ ‫ﺳﻠﻴﻢ‬ ‫ﺷﺨﺺ‬ ‫اﻟﻤﺮﺿﻰ‬ ‫ﻟﻤﺠﻤﻮﻋﺔ‬ ‫ﻣﻘﺎرﺑﺔ‬ ‫س‬ ‫ﺿﺒﻂ‬ ‫آﻤﺠﻤﻮﻋﺔ‬. ‫اﻟ…