Prevalence of symptomatic urinary tract infections and antimicrobial susceptibility patterns of isolated uropathogens in kohat region of Pakistan

Abstract

Urinary tract infections are commonly distributed infectious diseases. This study is designed to determine the prevalence of symptomatic UTIs and antimicrobial susceptibility patterns of uropathogens to commonly use antibiotics. A total of 500 patients, age ranges 20-90years were included in this study that conducted in Kohat Teaching Hospital of Kohat District, Khyber Pakhtunkhwa, Pakistan. Midstream urine samples were collected from patients of both genders. All samples were cultured aerobically in Blood agar, MaCconkey agar and CLED medium (Oxoid). The identification of isolated bacteria were performed using manual biochemical tests. All uropathogenic isolates were subjected to antimicrobial susceptibility testing. The prevalence of UTIs were 11.6%. The frequency of UTIs was 8.9% in males and 13.8% in females. Out of total positive cultures, 20.7% (12/58) were Gram positive bacteria and 79.3(46/58) were Gram negative bacteria. The commonly isolated pathogens are Escherichia coli 24 (41.4%), Klebsiella pneumoniae 9 (15.5%) and Proteus mirabilis 8 (13.8%). Most lactose fermenter Gram-ve bacteria were sensitive to Cefepime and all Gram positive isolates were sensitive to Meropenem. In this study, it was concluded that there is marked variation in the prevalence of UTIs (between males and females) and antibiotics susceptibility patterns of uropathogens. Meropenem is appropriate antibiotics to treated UTIs causes by Gram positive bacteria. These data demonstrate that future studies should be focused on the causes of antibiotics resistance to solve this problem.