Th1 and Th17 join forces for acute GVHD

Abstract

In this issue of Blood, Yu and colleagues demonstrate that combined targeted disruption of transcription factors T-bet and RORγt have defective differentiation of donor CD4+ T cells toward T helper 1 (Th1) and Th17, and ameliorated graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT).1.