Development of novel nickel- and palladium-catalyzed cycloaddition reactions which proceed with high atom economy

Abstract

In this review we report our development and applications of the highly selective cycloaddition reactions of unsaturated hydrocarbons such as conjugated enynes, electron-deficient allenes, and electron-deficient methylenecyclopropanes in the presence of nickel and palladium catalysts. Homocoupling reactions as well as co-cyclization reactions proceed with high atom economy, which is an attractive feature of these reactions. The efficient synthesis of 4-7 membered carbocycles was achieved. © 2005 The Pharmaceutical Society of Japan.