Treatment of colchicine-resistant familial mediterranean fever with anakinra

Abstract

Introduction: Familial Mediterranean Fever (FMF) is an auto-inflammatory disease presenting with periodic fever and various clinical manifestations. Almost 10% of the patients with FMF do not respond to colchicine therapy. Case Presentation: Herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of FMF. She had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. Addition of recombinant interleukin-1 receptor antagonist (Anakinra) to colchicine was effective to decrease the number and severity of abdominal pain in the patient. Conclusions: This case showed the effect of additional Anakinra on children with FMF who were colchicine resistant.