Aspirin and Hormone Therapy for Prostate Cancer

Abstract

To the Editor: Abnormal liver-function tests have been reported in 5% of patients taking high-dose aspirin for rheumatoid arthritis or osteoarthritis.1 A study of castrated rabbits revealed that serum levels of acetylsalicylic acid after oral aspirin administration were significantly higher than expected.2 This effect was attributed to slow metabolism of aspirin as a result of low testosterone levels. In men with prostate cancer, this effect of aspirin on liver-function tests could have clinical importance because the antiandrogen component of hormone therapy is discontinued when liver-function tests become abnormal. We investigated whether the use of low-dose aspirin affects liver-function tests, and . . .