F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing

Abstract

Background: The amyloid precursor protein (APP) is strongly implicated in the pathogenesis of Alzheimer disease. Results: The loss of Fbxo2, a brain-enriched substrate adaptor for ubiquitin ligases, leads to increased neuronal APP levels and processing. Conclusion: Fbxo2 regulates APP levels in a brain region-specific manner. Significance: These findings suggest a novel mechanism for ubiquitin-mediated regulation of amyloid-β production. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.