IDF21-0512 Development of Latent Autoimmune Diabetes of Adults Post SARS-COV-2 mRNA Vaccination

Abstract

Background: Latent autoimmune diabetes of adults (LADA) is a rare form of diabetes among elderly. To our knowledge this report presents the first case of new onset LADA in a patient with a history of non insulin dependent diabetes post-SARS-CoV-2 mRNA vaccination. Method: Case report and critical literature review. Results: 74 y/o with well controlled type 2 diabetes solely on metformin for six years prior to vaccination with Pfizer/BNT162b2 mRNA vaccine, developed severe thrombocytopenia two week-post vaccination, leading to hospitalization. Patient was treated with IVIG and steroids for presumed ITP. Because patient’s blood glucose levels remained elevated after discharge from the hospital, serum anti-GAD65 antibodies were ordered. Progressively rising antibody titers confirmed LADA and insulin therapy was initiated. Discussion: Immune exacerbation post-mRNA vaccination may result in autoimmunity. Screening for T1D/LADA and other autoimmune diseases may be needed post mRNA vaccination among those prone to autoimmunity especially now that mRNA vaccination for adolescents and children has been cleared by regulatory agencies worldwide.