In vitro screening of Cleome viscosa extract for anthelmintic activity

Abstract

The crude alcohol and aqueous extracts of the seeds of Cleome viscosa Linn. (Capparidaceae) were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli. Various concentrations (10-100 mg/mL) of each extract were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. Both extracts exhibited considerable anthelmintic activity in a dose-dependent manner. The most significant activity was observed at the highest concentration of 100 mg/mL against both types of worms. Piperazine citrate (10 mg/mL) was included as standard reference and distilled water as control. © 2007 Informa Healthcare USA, Inc.