Bullous pemphigoid

Abstract

Bullous pemphigoid (BP) is a chronic blistering dermatosis characterized by the subepidermal separation within the lamina lucida of the epidermal basement membrane zone (BMZ). BP was individualized in 1965 by Lever, who divided what was known as Duhring-Brocq disease into two distinct clinical entities: BP and dermatitis herpetiformis (DH). Clinical originality, immunopathology, electron microscopy, and immunomicroscopy are used to detect and independent bullous autoimmune disease. This study will review the clinical and biological aspects of the disease and present recently acquired knowledge regarding the immuno- and physiopathology of BP, followed by an account of its differential diagnosis and treatment.