Fish protein intake is a novel dietary approach for managing diabetes-associated complications in diabetic Wistar rat model

Abstract

Diabetes mellitus is a metabolic disorder associated with short term as well as long-term undesirable complications caused by persistent hyperglycemia. Recently, there has been emerging evidence that natural foods and their bioactive compounds are the key contributors to the treatment of diabetes and associated complications. This study was designed to explore the therapeutic efficacy of a fish protein-rich diet for managing diabetes and associated complications in the diabetic Wistar rat model. A high-protein (HP) diet (45% and 55% fish protein rich in ω3 fatty acids) was given to alloxan-induced diabetic rats for 28 days. Blood samples were collected for monitoring serum glucose, oxidative stress markers, lipid profile, kidney function markers, serum proteins, and liver function markers. Results indicated that there was a noteworthy control (p