Neurotuberculosis: Control of Steroid-Refractory Paradoxical Inflammatory Reaction with Ruxolitinib

Abstract

Paradoxical inflammatory reactions associated with treatment of neurotuberculosis can lead to severe morbidity and mortality and may not be controlled by steroids alone. We report the use of the Janus kinase inhibitor ruxolitinib to treat a steroid-refractory neurotuberculosis paradoxical reaction.