Facile synthesis of 5-hydroxy-3-pyrrolin-2-ones from morita-baylis-hillman adducts

Abstract

An efficient synthetic method of various 5-hydroxy-3-pyrrolin-2-one derivatives has been developed starting from the MBH adducts. In addition, some synthetic applicability of the prepared 5-hydroxy-3-pyrrolin-2-ones was demonstrated including the synthesis of lactam-fused tetrahydroisoquinolines. © 2005 KCSNET.