Adenomatoid odontogenic tumor expressing p53 and PCNA: A true benign neoplasm?

Abstract

Adenomatoid odontogenic tumor (AOT) is a relatively uncommon distinct odontogenic neoplasm. Histogenesis of AOT is still uncertain, and whether it represents anomalous hamartomatous growth or a true benign neoplasm is debatable. We report herein an unusual case of AOT occurring in the mandible. The tumor showed an unusual and aggressive clinical course, location, and radiographical and histopathological features expressing PCNA and p53 protein, which are suggestive of its proliferative potential, aggressive tumor behavior, and invasive characteristics. Based on these evidences, we suggested it to be a benign aggressive neoplasm rather than a hamartoma, though based on the analysis of single case it is still debatable.