The impact of dapagliflozin on HbA1c, systolic blood pressure and weight: a review of dapagliflozin use in a Scottish city

Abstract

We aimed to determine the efficacy of dapagliflozin in the management of type 2 diabetes in a Scottish population through measurements of glycaemic control, blood pressure and weight. Dapagliflozin was effective in improving HbA1c by 10 mmol/mol (SE 1.8, p < 0.001), systolic blood pressure by 9.8mmHg (SE 2.2, p < 0.001) and weight by 3.2 kg (SE 0.6, p < 0.001). There was a significant proportion of people with diabetes who reported side effects with dapagliflozin relating to genital and urinary tract infections. Dapagliflozin appears to be an effective drug in improving HbA1c, systolic blood pressure and weight in people with type 2 diabetes. However, in this cohort a substantial proportion of people with diabetes did not tolerate this drug due to side effects. Copyright © 2017 John Wiley & Sons.