Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

Abstract

Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.