Synthetic studies on keramaphidin B: Formation of a macrocyclic ring by intramolecular Diels-Alder reaction

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Abstract

The possibility of constructing the macrocyclic ring of keramaphidin B via an intramolecular Diels-Alder (IMDA) reaction has been investigated. The IMDA reaction of a substrate possessing dihydropyridone and diene moieties, which were tethered by an alkyl chain including a linear triple bond, was found to proceed in the presence of SnCl4 at 80 °C.

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Shimoda, H., Shibata, T., Sekine, D., & Nakada, M. (2020). Synthetic studies on keramaphidin B: Formation of a macrocyclic ring by intramolecular Diels-Alder reaction. Heterocycles, 100(1), 3–11. https://doi.org/10.3987/COM-19-14117

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