Effects of somatostatin combined with pantoprazole on serum C-reactive protein and intercellular adhesion molecule-1 in severe acute pancreatitis

Abstract

The objective of this study was to investigate effects of somatostatin combined with pantoprazole on serum C-reactive protein (CRP) and intercellular adhesion molecule-1 (ICAM-1) in severe acute pancreatitis (SAP) patients. It was an experimental study carried out from February 2016 to April 2018. Eighty-two patients were randomly divided into group A and group B with 41 in each group. Pantoprazole was used in group A and somatostatin combined with pantoprazole was used in group B. Results showed that time of abdominal pain relief, intestinal function recovery and ventilator weaning in group B were shorter than those in group A (all p<0.001). After treatment, levels of CRP and ICAM-1 in group B were lower than those in group A (both p<0.001). Compared with pantoprazole alone, somatostatin combined with pantoprazole has a better therapeutic effect on SAP, and its mechanism may be related to reduction of serum CRP and ICAM-1.