Synthesis and antimicrobial activity of some new Pyrazolo quinazoline derivatives

Abstract

Pyrazolo[5,1-b]quinazolines are known to be versatile heterocyclic compounds with different biological properties because of a large number of derivatives with different structural modifications. Therefore, some new Pyrazolo quinazoline heterocycles were synthesized from chalcones and their structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectral data. All these synthesized compounds were tested in vitro for their antimicrobial potential against Gram positive, Gram negative strains of bacteria as well as fungal strains in dimethylsulfoxide. Among the screened compounds, KC-10 showed the most potent antimicrobial activity. None of the compound shows antifungal activity. This may be due to the fact that fungal cells are complex organisms as compared to bacterial cell. Furthermore, the presence of S-CH3 group in the synthesized compounds may cause inactive behavior of these compounds against the studied fungal strains.